[The four following books and the beginning of Book XI, which are lost, contained the history of a period of nearly ten years, from A.D. 37 to A.D. 47. These years included the reign of Caius Caesar (Caligula), the son of Germanicus by the elder Agrippina, and the first six years of the reign of Claudius. Caius Caesar's reign was three years ten months and eight days in duration. Claudius (Tiberius Claudius Drusus Nero Germanicus), the brother of Germanicus, succeeded him, at the age of fifty, and reigned from A.D. 41 to A.D. 54.

The Eleventh Book of the Annals opens with the seventh year of Claudius's reign. The power of his wife Messalina was then at its height. She was, it seems, jealous of a certain Poppaea Sabina, who is mentioned in Book XIII., as "having surpassed in beauty all the ladies of her day." This Poppaea was the daughter of the Poppaeus Sabinus alluded to in Book VI., and the mother of the more famous Poppaea, afterwards the wife of the emperor Nero. Messalina contrived to involve this lady and her lover, Valerius Asiaticus, in a ruinous charge. Asiaticus had been twice consul, once under Caius Caesar, a second time under Claudius in A.D. 46. He was rich as well as noble. The Eleventh Book, as we have it, begins with the account of his prosecution by means Messalina, who with the help of Lucius Vitellius, Vitellius, father of the Vitellius, afterwards emperor, effected his ruin.]