Part, Chapter, Paragraph
1 I, 2. 3 | Childlessness is rather rare among minority groups, although
2 II, 5. 2. 2| below 35 years events are rare and above 74 years age structure
3 II, 5. 5. 3| groups~ ~Eating disorders are rare in population and affect
4 II, 5. 5. 3| s syndrome. This rather rare condition was described
5 II, 5. 5. 3| development. Although apparently rare the condition has probably
6 II, 5. 5. 3| seizure-related mortality is rare in new onset epilepsy, in
7 II, 5. 5. 3| Jallon, 2004). SUDEP is rare in community-based series
8 II, 5. 6. 3| and RA. The onset of RA is rare during pregnancy and RA
9 II, 5. 7. 1| that CKD at this age is rare (Ardissino et al, 2003;
10 II, 5. 7. 1| registries in Europe. Although rare, CKD and ESRD in children
11 II, 5. 11. 3| time during their lives.~ ~Rare skin diseases~Historically,
12 II, 5. 11. 3| forget the importance of rare skin diseases such as epidermolysis
13 II, 5. 11. 3| perspective. The study of such rare skin diseases is an area
14 II, 5. 11. 4| bullosa and many others. Rare skin diseases such as blistering
15 II, 5. 14. 3| early-onset periodontitis are rare. Moderate periodontitis
16 II, 5. 15.Acr| National Organization of Rare Disorders~OD~Orphan Drugs~
17 II, 5. 15. 1| Introduction~ ~The concept of “rare disease” (RD) emerged more
18 II, 5. 15. 1| when a disease becomes “rare”. Such a definition depends
19 II, 5. 15. 1| condition is considered “rare” when the health professionals
20 II, 5. 15. 1| policy specific for each rare disease, it is possible -
21 II, 5. 15. 1| although the impact of each rare disease is limited, rare diseases
22 II, 5. 15. 2| genetic diseases which are rare. The definition of what
23 II, 5. 15. 2| but also infectious RD, rare intoxications, auto-immune
24 II, 5. 15. 2| National Organization of Rare Disorders (NORD database,
25 II, 5. 15. 3| are included in the list. Rare tumours, for instance, are
26 II, 5. 15. 3| drugs developed for a rare condition. The European
27 II, 5. 15. 3| although they are intended for rare conditions where there are
28 II, 5. 15. 3| mendelian genetic disorders are rare as the causal mutations
29 II, 5. 15. 3| mutation, especially for very rare conditions. The consanguinity
30 II, 5. 15. 4| reference for a specific rare disease or a group of rare diseases (
31 II, 5. 15. 4| rare diseases (Cystic Fibrosis, Rare bleeding disorders, Alpha
32 II, 5. 15. 4| This sector will include rare mendelian phenotypes of
33 II, 5. 15. 5| professionals confronted with very rare conditions; will improve
34 II, 6. 3. 3| plasma-derived products became rare, as routine HCV tests became
35 II, 6. 3. 4| countries TB is becoming a rare disease and many Member
36 II, 6. 3. 4| cases of foreign origin rare, and levels of HIV and drug
37 II, 6. 3. 6| Botulism~ ~Botulism is a rare but serious paralytic illness
38 II, 6. 3. 7| missed. Though relatively rare, the disease has a worldwide
39 II, 9. 1. 1| among live births is not rare; it has increased during
40 II, 9. 1. 2| included in the figures). Many rare genetic disorders are diagnosed
41 II, 9. 1. 2| while in others TOPFA is rare (see above). This has resulted
42 II, 9. 1. 2| EUROCAT, 2007), but TOPFA is rare as the prognosis is good
43 II, 9. 1. 2| partially available for many rare anomalies. Inevitably, screening
44 II, 9. 1. 2| opportunity to pool data on rare anomalies and/or exposures,
45 II, 9. 1. 2| congenital anomalies are rare (as defined by prevalence
46 II, 9. 1. 2| 15) are congenital. The rare disease public health agenda,
47 II, 9. 1. 2| parental refusals are very rare, obtaining informed parental
48 II, 9. 3. 2| pregnancies. Although a very rare event, maternal mortality
49 III, 10. 2. 1| domestic-related activity are still rare.~ ~e) Data from accession
50 III, 10. 2. 2| incidence after 5 years. CHD is rare in populations with total
51 III, 10. 2. 4| affiliates are collecting data on rare genetic disorders (see Chapter
52 III, 10. 2. 4| diseases and also between rare and common diseases may
53 III, 10. 2. 4| phenotype (e.g. obesity) can be rare in the one case (e.g., due
54 III, 10. 2. 5| maternal malnutrition (being rare these days), placental dysfunction,
55 III, 10. 3. 1| in children are extremely rare and it is not known if childhood
56 III, 10. 4. 2| Unclear~Unclear~Listeriosis~Rare, but severe consequences~
57 III, 10. 4. 2| difficult or, in case of rare events, impossible to carry
58 III, 10. 5. 1| direct health effects are rare. On the other side, cockroaches
59 III, 10. 6. 1| cases. Absent contact was rare in all the participating
