Part,  Chapter, Paragraph

  1    I,     2. 10.  1    |             as the exposure to toxic substances (toxicogenomics) or the
  2   II,     5.  1.  1    |              potentially sensitizing substances such as metals, perfumes,
  3   II,     5.  5.  3    |            care.~ ~The main group of substances applied for treating schizophrenia
  4   II,     5.  5.  3    |      exclusively attributed to these substances since abnormalities of glucose
  5   II,     5.  9. FB    |          response to the exposure to substances that usually do not elicit
  6   II,     5.  9.  4    |          groups of workers: over 300 substances have been correlated to
  7   II,     5.  9.  4    |              the role of exposure to substances in the workplace in new-onset
  8   II,     5.  9.  4    |           was seen after exposure to substances known to cause occupational
  9   II,     5. 10.  5    |          list of food ingredients or substances that are known to trigger
 10   II,     5. 10.  5    |      Whenever the listed ingredients/substances or their derivatives are
 11   II,     5. 10.  5    |           regarding the labelling of substances or ingredients that may
 12   II,     5. 10.  5    |             List of food ingredients/substances subject to compulsory labelling
 13   II,     5. 10.  5    |             that some ingredients or substances, derived from allergens,
 14   II,     5. 10.  5    |             for these ingredients or substances. Commission Directive 2005/
 15   II,     5. 10.  5    |            EC establishing a list of substances provisionally exempted was
 16   II,     5. 10.  5    |       industry on the ingredients or substances for which temporary exemption
 17   II,     5. 10.  5    |               establishing a list of substances permanently exempted form
 18   II,     5. 10.  5    |         lists of food ingredients or substances under either mandatory labelling
 19   II,     5. 10.  6    |              be better achieved with substances responsible for non IgE-mediated
 20   II,     5. 10.  7    |          list of food ingredients or substances provisionally excluded from
 21   II,     5. 11.  3    |              potentially sensitizing substances such as metals in piercing (
 22   II,     5. 11.  3    |              allergic to one or more~substances when patch tested but the
 23   II,     6.  4.  5    |              sure that antibacterial substances are available by prescription
 24  III,    10.  1        |            factors such as hazardous substances in the outdoor and indoor
 25  III,    10.  2.  1    |       smoking releases 4000 chemical substances. In contrast, snuff contains
 26  III,    10.  2.  1    |              more than 2500 chemical substances, of which 28 are known cancerogens.
 27  III,    10.  2.  1    |           thousands of other harmful substances found in cigarettes and
 28  III,    10.  2.  1(1) |           Convention of Psychotropic Substances. (For further details see
 29  III,    10.  2.  1    |           most commonly used illicit substances in Europe, with some variations
 30  III,    10.  2.  1    |           opioid medications). Other substances, such as LSD, GHB, Ketamine
 31  III,    10.  2.  1    |            and the co-use of several substances are also increasing.~ ~Drug
 32  III,    10.  2.  1    |           physical properties of the substances, smoking, snorting, swallowing
 33  III,    10.  2.  1    |              of the use of different substances.~ ~On average, 30% (3-50%)
 34  III,    10.  2.  1    |             drug use, especially for substances with high addictive potential (
 35  III,    10.  2.  1    |           cocaine and multiple other substances, marginalized crack users,
 36  III,    10.  2.  1    |           multiple illicit and licit substances are used during the same
 37  III,    10.  2.  1    |              for 46% to 100%16.Other substances identified as having possibly
 38  III,    10.  2.  1    |          control of new psychoactive substances18.~Drug related problems
 39  III,    10.  2.  1    |            also in a few cases other substances (codeine, slow-release morphine,
 40  III,    10.  2.  1    |           use (the co-use of several substances) is now identified as a
 41  III,    10.  2.  1    |             to the use of controlled substances and many of those with substance
 42  III,    10.  2.  1    |      different patterns of co-use of substances and their consequences on
 43  III,    10.  2.  1    |              the use of psychoactive substances.~ ~Another challenge for
 44  III,    10.  2.  1    |        diffusion of new uncontrolled substances. The Internet now acts as
 45  III,    10.  2.  1    |   stimulating innovation. A range of substances, both synthetic and natural,
 46  III,    10.  2.  1    |            of different psychoactive substances that will remain the focus
 47  III,    10.  2.  1    |        minerals and of certain other substances to foods. The aim is to
 48  III,    10.  2.  1    |               Annex III is a list of substances whose use in foods is prohibited,
 49  III,    10.  2.  1    |         foods.~ ~Vitamin and mineral substances may be considered for inclusion
 50  III,    10.  2.  1    |               to restrict the use of substances added to foods or used in
 51  III,    10.  2.  1    |        minerals and of certain other substances to foods.~ ~Food supplements
 52  III,    10.  2.  1    |        sources of nutrients or other substances with a nutritional or physiological
 53  III,    10.  2.  1    |        amended to include additional substances. The trade of products containing
 54  III,    10.  2.  1    |          2005.~ ~Vitamin and mineral substances may be considered for inclusion
 55  III,    10.  2.  1    |              EFSA.~ ~The nutritional substances that can be added to foods
 56  III,    10.  2.  1    |            EC of 15 February 2001 on substances that may be added for specific
 57  III,    10.  2.  1    |             the inclusion of certain substances (Text with EEA relevance):~
 58  III,    10.  2.  1    |        minerals and of certain other substances to foods.~Official Journal
 59  III,    10.  2.  4    |             as the exposure to toxic substances (toxico-genomics) or the
 60  III,    10.  2.  5    |               Early life exposure to substances with estrogenic and androgenic
 61  III,    10.  2.  5    |              volume of water-soluble substances and to an increase of distribution
 62  III,    10.  2.  5    |   distribution volume of fat-soluble substances. Moreover, characteristic
 63  III,    10.  2.  5    |            of free fractions of many substances that would have been otherwise
 64  III,    10.  2.  5    |              bioavailability of many substances;~- deceased kidney haematic
 65  III,    10.  3.  1    | international ban on ozone-depleting substances begin. These environmental
 66  III,    10.  3.  1    |          phasing out ozone depleting substances. European countries have
 67  III,    10.  3.  1    |            in EU countries, relevant substances have been almost entirely
 68  III,    10.  3.  1    |       phasing-out of ozone-depleting substances will particularly benefit
 69  III,    10.  3.  2    |       napthalenes~PFS~Perflourinated substances~PGE~Platinum group elements~
 70  III,    10.  3.  2    |      Man-made or industrial chemical substances can be released during every
 71  III,    10.  3.  2    |            of chemical mixtures. For substances used in long life articles
 72  III,    10.  3.  2    |          This is one reason why some substances are still found in the environment
 73  III,    10.  3.  2    |          natural or human-made toxic substances in air, water, soil and
 74  III,    10.  3.  2    |    contamination by persistent toxic substances, ozone depletion, global
 75  III,    10.  3.  2    |            and on the environment.~ ~Substances of highest global concern
 76  III,    10.  3.  2    |              information on chemical substances (eChemPortal) htt The Japanese
 77  III,    10.  3.  2    |              increased by 23.5%. The substances of high concerncarcinogenic,
 78  III,    10.  3.  2    |            but also due to hazardous substances used in downstream industries.
 79  III,    10.  3.  2    |             of high amounts of toxic substances into the environment. (EEA
 80  III,    10.  3.  2    |       pan-European region~ ~Emerging substances and new concerns~ ~New uses,
 81  III,    10.  3.  2    |             PGEs) and perflourinated substances (PFS) are presented as examples
 82  III,    10.  3.  2    |       material and the fact that the substances are found in remote areas
 83  III,    10.  3.  2    |              on endocrine disrupting substances and neurodevelopment disorders (
 84  III,    10.  3.  2(25)|           and labelling of dangerous substances.~
 85  III,    10.  3.  2    |               Early life exposure to substances with estrogenic and androgenic
 86  III,    10.  3.  2    |             Endocrine disruptors are substances that potentially interfere
 87  III,    10.  3.  2    |              documented examples for substances causing endocrine disruption
 88  III,    10.  3.  2    |      persistent and bio-accumulative substances, but concentrations of other
 89  III,    10.  3.  2    |              concentrations of other substances are decreasing. Breast milk
 90  III,    10.  3.  2    |      persistent and bio-accumulative substances, although concentrations
 91  III,    10.  3.  2    |              concentrations of other substances are decreasing. As an example,
 92  III,    10.  3.  2    |            pyrotechnic and explosive substances – the case of Enschede fireworks
 93  III,    10.  3.  2    |    requirements for new and existing substances; shifting the burden of
 94  III,    10.  3.  2    |              and labelling hazardous substances, with a target date of 2008,
 95  III,    10.  3.  2    |           widespread use of chemical substances without or despite knowledge
 96  III,    10.  3.  2    |          which in case of persistent substances, substances used in long-life
 97  III,    10.  3.  2    |            of persistent substances, substances used in long-life articles,
 98  III,    10.  3.  2    |         after the production of such substances has been phased out.~There
 99  III,    10.  3.  2    |          hazards involving dangerous substances for the period 20032005.
100  III,    10.  3.  4    |            poisoning caused by toxic substances. Health effects are further
101  III,    10.  4.  2    |            naturally occurring toxic substances (Food Safety)~ ~
102  III,    10.  4.  2    |            additives and products or substances used in animal feed; (7)
103  III,    10.  4.  2    |            the peer review of active substances used in EU plant protection
104  III,    10.  4.  2    |              Non naturally occurring substances~ ~Chemical contaminants
105  III,    10.  4.  2    |          exposure~Remarks, sources~ ~Substances deliberately added to foods~ ~
106  III,    10.  4.  2    |            200a; Barlow et al.,~2002~Substances that are present in the
107  III,    10.  4.  2    |           animals~Approx. 400 active~substances admitted;~maximum residue
108  III,    10.  4.  2    |              1996~ ~Growth promoting~substances (naturally~present in the
109  III,    10.  4.  2    |            is not always clear which~substances should be~searched for~ ~
110  III,    10.  4.  2    |        between risks and benefits of substances that are used intentionally
111  III,    10.  4.  2    |              consumer,. For chemical substances in food, legislation is
112  III,    10.  4.  2    |        chemically defined flavouring substances a vast safety evaluation
113  III,    10.  4.  2    |           programme is ongoing. Only substances for which the outcome of
114  III,    10.  4.  2    |             in some cases the use of substances is prohibited.~• The legislation
115  III,    10.  4.  2    |           genotoxic and carcinogenic substances. Information about ongoing
116  III,    10.  4.  2    |          residues of about 85 active substances are being monitored in 27
117  III,    10.  4.  2    |             covered 44 to 631 active substances40. As a rough estimation
118  III,    10.  4.  2    |             assessment of the active substances, will establish the final
119  III,    10.  4.  2    |           and documented examples of substances causing endocrine disruption
120  III,    10.  4.  2    |                  Naturally occurring substances~ ~Moreover, a number of
121  III,    10.  4.  2    |            naturally-occurring toxic substances, identified in different
122  III,    10.  4.  2    |              constituents~Allergenic substances~Shellfish, fish, milk, nuts,~
123  III,    10.  4.  2    |            10)~ ~ ~Mycotoxins: toxic substances formed by moulds on crops~ ~ ~ ~ ~
124  III,    10.  4.  2    |            2001~ ~Phycotoxins; toxic substances formed by algae, and which
125  III,    10.  4.  2    |          2004~ ~ ~Phytotoxins; toxic substances that are formed in plants (
126  III,    10.  4.  2    |              250, 300 and 650 active substances, the situation is going
127  III,    10.  4.  2    |       Harmonised MRLs for all active substances;~· Review programme for
128  III,    10.  4.  2    |            ANNEXIV deals with active substances for which no MRLs are necessary(
129  III,    10.  4.  2    |     necessary(rather minor number of substances);~· A default MRL of 0,01
130  III,    10.  4.  2    |             kg applies to all active substances not explicitly mentioned(
131  III,    10.  4.  2    |     mentioned(a very large number of substances).~ ~EFSA tasks under Regulation
132  III,    10.  4.  2    |            assessment for all active substances for which temporary MRLs
133  III,    10.  4.  2    |            12;~· MRLs for all active substances included in Annex I of Dir.
134  III,    10.  4.  2    |              2008). About 170 active substances to be assessed;~· each active
135  III,    10.  4.  2    |              for inclusion of active substances in Annex IV to the Regulation,
136  III,    10.  4.  2    |           000 samples and 190 active substances for assessing the actual
137  III,    10.  4.  2    |                peer review of active substances.~ ~Within the framework
138  III,    10.  4.  2    |             evaluation of the active substances:~ ~· first: a designated
139  III,    10.  4.  2    |         status: evaluation of active substances.~ ~The immediate tasks for
140  III,    10.  4.  2    |             conclusions on 37 active substances from list 3 to the Commission
141  III,    10.  4.  2    |             conclusions on 11 active substances from list 4 to the Commission
142  III,    10.  4.  2    |          products;~· reassessment of substances included in annex 1 following
143  III,    10.  4.  2    |     introduced by the Commission for substances withdrawn by applicants
144  III,    10.  4.  2    |     assessment or on specific active substances based on questions from
145  III,    10.  4.  2    |           using a stepwise approach. Substances that share a common mode
146  III,    10.  4.  2    |            and the level of unwanted substances contained therein).~ ~Modern
147  III,    10.  4.  2    |        minerals and of certain other substances to foods. Official Journal
148  III,    10.  4.  2    |            EC of 15 February 2001 on substances that may be added for specific
149  III,    10.  4.  2    |             the inclusion of certain substances. Official Journal of the
150  III,    10.  4.  3    |             of 41 dangerous chemical substances (including 33 priority substances
151  III,    10.  4.  3    |    substances (including 33 priority substances and 8 other pollutants)
152  III,    10.  4.  3    |             of 41 dangerous chemical substances includes the 33 priority
153  III,    10.  4.  3    |             includes the 33 priority substances and 8 other pollutants.
154  III,    10.  4.  4    |          exposures to tin compounds, substances which may act as endocrine
155  III,    10.  4.  5    |             of 41 dangerous chemical substances includes the 33 priority
156  III,    10.  4.  5    |             includes the 33 priority substances and 8 other pollutants.
157  III,    10.  4.  5    |          contaminated with hazardous substances can have serious effects
158  III,    10.  4.  5    |           the reduction of hazardous substances in material streams and
159  III,    10.  4.  5    |              the types and amount of substances emanating from these sources.
160  III,    10.  4.  5    |            large number of different substances, with only few of them produced
161  III,    10.  4.  5    |    explosiveness. In addition to the substances above, they suggested that
162  III,    10.  5.  3    |      hazardous physical and chemical substances and straining psychosocial
163   IV,    11.  5.  4    |              exchange of therapeutic substances of human origin in 1958
164   IV,    11.  5.  6    |             transplantation of human substances~ ~· Recommendation No. R (
165   IV,    12.  1        |             and safety of organs and substances of human origin, blood and
166   IV,    12.  1        |              the case of therapeutic substances of human origin. While at
167   IV,    12.  2        |           thousands of other harmful substances found in cigarettes and
168   IV,    12.  5        |            and quality of organs and substances of human origin, blood,
169   IV,    12. 10        |                    Human therapeutic substances: quality, safety and ethics~
170   IV,    12. 10        |             disposal of the residual substances, both in the production
171   IV,    12. 10        |   implementation will take. Chemical substances that pose a risk to human
172   IV,    12. 10        |              handling of radioactive substances in nuclear technology and
173   IV,    12. 10        |      narcotic drugs and psychotropic substances listed in the schedules
174   IV,    12. 10        |            the schedules to the Act. Substances are scheduled under the
175   IV,    12. 10        |           there is evidence that the substances are causing significant
176   IV,    12. 10        |        Regulations 2004~- Control of Substances that deplete the Ozone Layer
177   IV,    12. 10        |              220 of 2003 - dangerous substances & preparations marketing
178   IV,    12. 10        |        prohibition of certain active substances in plant protection products~ ~
179   IV,    12. 10        |             2037/2000 concerning the substances which destroy the layer
180   IV,    12. 10        |             use of certain hazardous substances in electrical and electronic
181   IV,    12. 10        |            Narcotic and Psychotropic Substances and Medical Products~ State
182   IV,    13.  2.  3    |          than that caused by various substances found in the environment.
183   IV,    13.  2.  3    |              0175 (5)~PAHs (5) other substances~ ~Various substances~ ~ ~
184   IV,    13.  2.  3    |           other substances~ ~Various substances~ ~ ~1. Here, ‘unhealthy