Part,  Chapter, Paragraph

 1    I,     2.  3    |             Childlessness is rather rare among minority groups, although
 2   II,     5.  2.  2|           below 35 years events are rare and above 74 years age structure
 3   II,     5.  5.  3|       groups~ ~Eating disorders are rare in population and affect
 4   II,     5.  5.  3|             s syndrome. This rather rare condition was described
 5   II,     5.  5.  3|    development. Although apparently rare the condition has probably
 6   II,     5.  5.  3|        seizure-related mortality is rare in new onset epilepsy, in
 7   II,     5.  5.  3|             Jallon, 2004). SUDEP is rare in community-based series
 8   II,     5.  6.  3|          and RA. The onset of RA is rare during pregnancy and RA
 9   II,     5.  7.  1|             that CKD at this age is rare (Ardissino et al, 2003;
10   II,     5.  7.  1|      registries in Europe. Although rare, CKD and ESRD in children
11   II,     5. 11.  3|          time during their lives.~ ~Rare skin diseases~Historically,
12   II,     5. 11.  3|            forget the importance of rare skin diseases such as epidermolysis
13   II,     5. 11.  3|      perspective. The study of such rare skin diseases is an area
14   II,     5. 11.  4|            bullosa and many others. Rare skin diseases such as blistering
15   II,     5. 14.  3|       early-onset periodontitis are rare. Moderate periodontitis
16   II,     5. 15.Acr|            National Organization of Rare Disorders~OD~Orphan Drugs~
17   II,     5. 15.  1|      Introduction~ ~The concept of “rare disease” (RD) emerged more
18   II,     5. 15.  1|             when a disease becomes “rare”. Such a definition depends
19   II,     5. 15.  1|            condition is consideredrare” when the health professionals
20   II,     5. 15.  1|            policy specific for each rare disease, it is possible -
21   II,     5. 15.  1|         although the impact of each rare disease is limited, rare diseases
22   II,     5. 15.  2|          genetic diseases which are rare. The definition of what
23   II,     5. 15.  2|             but also infectious RD, rare intoxications, auto-immune
24   II,     5. 15.  2|            National Organization of Rare Disorders (NORD database,
25   II,     5. 15.  3|           are included in the list. Rare tumours, for instance, are
26   II,     5. 15.  3|               drugs developed for a rare condition. The European
27   II,     5. 15.  3|      although they are intended for rare conditions where there are
28   II,     5. 15.  3|     mendelian genetic disorders are rare as the causal mutations
29   II,     5. 15.  3|       mutation, especially for very rare conditions. The consanguinity
30   II,     5. 15.  4|            reference for a specific rare disease or a group of rare diseases (
31   II,     5. 15.  4|     rare diseases (Cystic Fibrosis, Rare bleeding disorders, Alpha
32   II,     5. 15.  4|            This sector will include rare mendelian phenotypes of
33   II,     5. 15.  5|  professionals confronted with very rare conditions; will improve
34   II,     6.  3.  3|      plasma-derived products became rare, as routine HCV tests became
35   II,     6.  3.  4|          countries TB is becoming a rare disease and many Member
36   II,     6.  3.  4|             cases of foreign origin rare, and levels of HIV and drug
37   II,     6.  3.  6|            Botulism~ ~Botulism is a rare but serious paralytic illness
38   II,     6.  3.  7|           missed. Though relatively rare, the disease has a worldwide
39   II,     9.  1.  1|            among live births is not rare; it has increased during
40   II,     9.  1.  2|      included in the figures). Many rare genetic disorders are diagnosed
41   II,     9.  1.  2|            while in others TOPFA is rare (see above). This has resulted
42   II,     9.  1.  2|        EUROCAT, 2007), but TOPFA is rare as the prognosis is good
43   II,     9.  1.  2|        partially available for many rare anomalies. Inevitably, screening
44   II,     9.  1.  2|         opportunity to pool data on rare anomalies and/or exposures,
45   II,     9.  1.  2|            congenital anomalies are rare (as defined by prevalence
46   II,     9.  1.  2|             15) are congenital. The rare disease public health agenda,
47   II,     9.  1.  2|          parental refusals are very rare, obtaining informed parental
48   II,     9.  3.  2|        pregnancies. Although a very rare event, maternal mortality
49  III,    10.  2.  1| domestic-related activity are still rare.~ ~e) Data from accession
50  III,    10.  2.  2|     incidence after 5 years. CHD is rare in populations with total
51  III,    10.  2.  4|   affiliates are collecting data on rare genetic disorders (see Chapter
52  III,    10.  2.  4|           diseases and also between rare and common diseases may
53  III,    10.  2.  4|     phenotype (e.g. obesity) can be rare in the one case (e.g., due
54  III,    10.  2.  5|        maternal malnutrition (being rare these days), placental dysfunction,
55  III,    10.  3.  1|           in children are extremely rare and it is not known if childhood
56  III,    10.  4.  2|         Unclear~Unclear~Listeriosis~Rare, but severe consequences~
57  III,    10.  4.  2|            difficult or, in case of rare events, impossible to carry
58  III,    10.  5.  1|           direct health effects are rare. On the other side, cockroaches
59  III,    10.  6.  1|           cases. Absent contact was rare in all the participating