Part, Chapter, Paragraph
1 I, 2. 10. 1 | as the exposure to toxic substances (toxicogenomics) or the
2 II, 5. 1. 1 | potentially sensitizing substances such as metals, perfumes,
3 II, 5. 5. 3 | care.~ ~The main group of substances applied for treating schizophrenia
4 II, 5. 5. 3 | exclusively attributed to these substances since abnormalities of glucose
5 II, 5. 9. FB | response to the exposure to substances that usually do not elicit
6 II, 5. 9. 4 | groups of workers: over 300 substances have been correlated to
7 II, 5. 9. 4 | the role of exposure to substances in the workplace in new-onset
8 II, 5. 9. 4 | was seen after exposure to substances known to cause occupational
9 II, 5. 10. 5 | list of food ingredients or substances that are known to trigger
10 II, 5. 10. 5 | Whenever the listed ingredients/substances or their derivatives are
11 II, 5. 10. 5 | regarding the labelling of substances or ingredients that may
12 II, 5. 10. 5 | List of food ingredients/substances subject to compulsory labelling
13 II, 5. 10. 5 | that some ingredients or substances, derived from allergens,
14 II, 5. 10. 5 | for these ingredients or substances. Commission Directive 2005/
15 II, 5. 10. 5 | EC establishing a list of substances provisionally exempted was
16 II, 5. 10. 5 | industry on the ingredients or substances for which temporary exemption
17 II, 5. 10. 5 | establishing a list of substances permanently exempted form
18 II, 5. 10. 5 | lists of food ingredients or substances under either mandatory labelling
19 II, 5. 10. 6 | be better achieved with substances responsible for non IgE-mediated
20 II, 5. 10. 7 | list of food ingredients or substances provisionally excluded from
21 II, 5. 11. 3 | potentially sensitizing substances such as metals in piercing (
22 II, 5. 11. 3 | allergic to one or more~substances when patch tested but the
23 II, 6. 4. 5 | sure that antibacterial substances are available by prescription
24 III, 10. 1 | factors such as hazardous substances in the outdoor and indoor
25 III, 10. 2. 1 | smoking releases 4000 chemical substances. In contrast, snuff contains
26 III, 10. 2. 1 | more than 2500 chemical substances, of which 28 are known cancerogens.
27 III, 10. 2. 1 | thousands of other harmful substances found in cigarettes and
28 III, 10. 2. 1(1) | Convention of Psychotropic Substances. (For further details see
29 III, 10. 2. 1 | most commonly used illicit substances in Europe, with some variations
30 III, 10. 2. 1 | opioid medications). Other substances, such as LSD, GHB, Ketamine
31 III, 10. 2. 1 | and the co-use of several substances are also increasing.~ ~Drug
32 III, 10. 2. 1 | physical properties of the substances, smoking, snorting, swallowing
33 III, 10. 2. 1 | of the use of different substances.~ ~On average, 30% (3-50%)
34 III, 10. 2. 1 | drug use, especially for substances with high addictive potential (
35 III, 10. 2. 1 | cocaine and multiple other substances, marginalized crack users,
36 III, 10. 2. 1 | multiple illicit and licit substances are used during the same
37 III, 10. 2. 1 | for 46% to 100%16.Other substances identified as having possibly
38 III, 10. 2. 1 | control of new psychoactive substances18.~Drug related problems
39 III, 10. 2. 1 | also in a few cases other substances (codeine, slow-release morphine,
40 III, 10. 2. 1 | use (the co-use of several substances) is now identified as a
41 III, 10. 2. 1 | to the use of controlled substances and many of those with substance
42 III, 10. 2. 1 | different patterns of co-use of substances and their consequences on
43 III, 10. 2. 1 | the use of psychoactive substances.~ ~Another challenge for
44 III, 10. 2. 1 | diffusion of new uncontrolled substances. The Internet now acts as
45 III, 10. 2. 1 | stimulating innovation. A range of substances, both synthetic and natural,
46 III, 10. 2. 1 | of different psychoactive substances that will remain the focus
47 III, 10. 2. 1 | minerals and of certain other substances to foods. The aim is to
48 III, 10. 2. 1 | Annex III is a list of substances whose use in foods is prohibited,
49 III, 10. 2. 1 | foods.~ ~Vitamin and mineral substances may be considered for inclusion
50 III, 10. 2. 1 | to restrict the use of substances added to foods or used in
51 III, 10. 2. 1 | minerals and of certain other substances to foods.~ ~Food supplements
52 III, 10. 2. 1 | sources of nutrients or other substances with a nutritional or physiological
53 III, 10. 2. 1 | amended to include additional substances. The trade of products containing
54 III, 10. 2. 1 | 2005.~ ~Vitamin and mineral substances may be considered for inclusion
55 III, 10. 2. 1 | EFSA.~ ~The nutritional substances that can be added to foods
56 III, 10. 2. 1 | EC of 15 February 2001 on substances that may be added for specific
57 III, 10. 2. 1 | the inclusion of certain substances (Text with EEA relevance):~
58 III, 10. 2. 1 | minerals and of certain other substances to foods.~Official Journal
59 III, 10. 2. 4 | as the exposure to toxic substances (toxico-genomics) or the
60 III, 10. 2. 5 | Early life exposure to substances with estrogenic and androgenic
61 III, 10. 2. 5 | volume of water-soluble substances and to an increase of distribution
62 III, 10. 2. 5 | distribution volume of fat-soluble substances. Moreover, characteristic
63 III, 10. 2. 5 | of free fractions of many substances that would have been otherwise
64 III, 10. 2. 5 | bioavailability of many substances;~- deceased kidney haematic
65 III, 10. 3. 1 | international ban on ozone-depleting substances begin. These environmental
66 III, 10. 3. 1 | phasing out ozone depleting substances. European countries have
67 III, 10. 3. 1 | in EU countries, relevant substances have been almost entirely
68 III, 10. 3. 1 | phasing-out of ozone-depleting substances will particularly benefit
69 III, 10. 3. 2 | napthalenes~PFS~Perflourinated substances~PGE~Platinum group elements~
70 III, 10. 3. 2 | Man-made or industrial chemical substances can be released during every
71 III, 10. 3. 2 | of chemical mixtures. For substances used in long life articles
72 III, 10. 3. 2 | This is one reason why some substances are still found in the environment
73 III, 10. 3. 2 | natural or human-made toxic substances in air, water, soil and
74 III, 10. 3. 2 | contamination by persistent toxic substances, ozone depletion, global
75 III, 10. 3. 2 | and on the environment.~ ~Substances of highest global concern
76 III, 10. 3. 2 | information on chemical substances (eChemPortal) htt The Japanese
77 III, 10. 3. 2 | increased by 23.5%. The substances of high concern – carcinogenic,
78 III, 10. 3. 2 | but also due to hazardous substances used in downstream industries.
79 III, 10. 3. 2 | of high amounts of toxic substances into the environment. (EEA
80 III, 10. 3. 2 | pan-European region~ ~Emerging substances and new concerns~ ~New uses,
81 III, 10. 3. 2 | PGEs) and perflourinated substances (PFS) are presented as examples
82 III, 10. 3. 2 | material and the fact that the substances are found in remote areas
83 III, 10. 3. 2 | on endocrine disrupting substances and neurodevelopment disorders (
84 III, 10. 3. 2(25)| and labelling of dangerous substances.~
85 III, 10. 3. 2 | Early life exposure to substances with estrogenic and androgenic
86 III, 10. 3. 2 | Endocrine disruptors are substances that potentially interfere
87 III, 10. 3. 2 | documented examples for substances causing endocrine disruption
88 III, 10. 3. 2 | persistent and bio-accumulative substances, but concentrations of other
89 III, 10. 3. 2 | concentrations of other substances are decreasing. Breast milk
90 III, 10. 3. 2 | persistent and bio-accumulative substances, although concentrations
91 III, 10. 3. 2 | concentrations of other substances are decreasing. As an example,
92 III, 10. 3. 2 | pyrotechnic and explosive substances – the case of Enschede fireworks
93 III, 10. 3. 2 | requirements for new and existing substances; shifting the burden of
94 III, 10. 3. 2 | and labelling hazardous substances, with a target date of 2008,
95 III, 10. 3. 2 | widespread use of chemical substances without or despite knowledge
96 III, 10. 3. 2 | which in case of persistent substances, substances used in long-life
97 III, 10. 3. 2 | of persistent substances, substances used in long-life articles,
98 III, 10. 3. 2 | after the production of such substances has been phased out.~There
99 III, 10. 3. 2 | hazards involving dangerous substances for the period 2003 – 2005.
100 III, 10. 3. 4 | poisoning caused by toxic substances. Health effects are further
101 III, 10. 4. 2 | naturally occurring toxic substances (Food Safety)~ ~
102 III, 10. 4. 2 | additives and products or substances used in animal feed; (7)
103 III, 10. 4. 2 | the peer review of active substances used in EU plant protection
104 III, 10. 4. 2 | Non naturally occurring substances~ ~Chemical contaminants
105 III, 10. 4. 2 | exposure~Remarks, sources~ ~Substances deliberately added to foods~ ~
106 III, 10. 4. 2 | 200a; Barlow et al.,~2002~Substances that are present in the
107 III, 10. 4. 2 | animals~Approx. 400 active~substances admitted;~maximum residue
108 III, 10. 4. 2 | 1996~ ~Growth promoting~substances (naturally~present in the
109 III, 10. 4. 2 | is not always clear which~substances should be~searched for~ ~
110 III, 10. 4. 2 | between risks and benefits of substances that are used intentionally
111 III, 10. 4. 2 | consumer,. For chemical substances in food, legislation is
112 III, 10. 4. 2 | chemically defined flavouring substances a vast safety evaluation
113 III, 10. 4. 2 | programme is ongoing. Only substances for which the outcome of
114 III, 10. 4. 2 | in some cases the use of substances is prohibited.~• The legislation
115 III, 10. 4. 2 | genotoxic and carcinogenic substances. Information about ongoing
116 III, 10. 4. 2 | residues of about 85 active substances are being monitored in 27
117 III, 10. 4. 2 | covered 44 to 631 active substances40. As a rough estimation
118 III, 10. 4. 2 | assessment of the active substances, will establish the final
119 III, 10. 4. 2 | and documented examples of substances causing endocrine disruption
120 III, 10. 4. 2 | Naturally occurring substances~ ~Moreover, a number of
121 III, 10. 4. 2 | naturally-occurring toxic substances, identified in different
122 III, 10. 4. 2 | constituents~Allergenic substances~Shellfish, fish, milk, nuts,~
123 III, 10. 4. 2 | 10)~ ~ ~Mycotoxins: toxic substances formed by moulds on crops~ ~ ~ ~ ~
124 III, 10. 4. 2 | 2001~ ~Phycotoxins; toxic substances formed by algae, and which
125 III, 10. 4. 2 | 2004~ ~ ~Phytotoxins; toxic substances that are formed in plants (
126 III, 10. 4. 2 | 250, 300 and 650 active substances, the situation is going
127 III, 10. 4. 2 | Harmonised MRLs for all active substances;~· Review programme for
128 III, 10. 4. 2 | ANNEXIV deals with active substances for which no MRLs are necessary(
129 III, 10. 4. 2 | necessary(rather minor number of substances);~· A default MRL of 0,01
130 III, 10. 4. 2 | kg applies to all active substances not explicitly mentioned(
131 III, 10. 4. 2 | mentioned(a very large number of substances).~ ~EFSA tasks under Regulation
132 III, 10. 4. 2 | assessment for all active substances for which temporary MRLs
133 III, 10. 4. 2 | 12;~· MRLs for all active substances included in Annex I of Dir.
134 III, 10. 4. 2 | 2008). About 170 active substances to be assessed;~· each active
135 III, 10. 4. 2 | for inclusion of active substances in Annex IV to the Regulation,
136 III, 10. 4. 2 | 000 samples and 190 active substances for assessing the actual
137 III, 10. 4. 2 | peer review of active substances.~ ~Within the framework
138 III, 10. 4. 2 | evaluation of the active substances:~ ~· first: a designated
139 III, 10. 4. 2 | status: evaluation of active substances.~ ~The immediate tasks for
140 III, 10. 4. 2 | conclusions on 37 active substances from list 3 to the Commission
141 III, 10. 4. 2 | conclusions on 11 active substances from list 4 to the Commission
142 III, 10. 4. 2 | products;~· reassessment of substances included in annex 1 following
143 III, 10. 4. 2 | introduced by the Commission for substances withdrawn by applicants
144 III, 10. 4. 2 | assessment or on specific active substances based on questions from
145 III, 10. 4. 2 | using a stepwise approach. Substances that share a common mode
146 III, 10. 4. 2 | and the level of unwanted substances contained therein).~ ~Modern
147 III, 10. 4. 2 | minerals and of certain other substances to foods. Official Journal
148 III, 10. 4. 2 | EC of 15 February 2001 on substances that may be added for specific
149 III, 10. 4. 2 | the inclusion of certain substances. Official Journal of the
150 III, 10. 4. 3 | of 41 dangerous chemical substances (including 33 priority substances
151 III, 10. 4. 3 | substances (including 33 priority substances and 8 other pollutants)
152 III, 10. 4. 3 | of 41 dangerous chemical substances includes the 33 priority
153 III, 10. 4. 3 | includes the 33 priority substances and 8 other pollutants.
154 III, 10. 4. 4 | exposures to tin compounds, substances which may act as endocrine
155 III, 10. 4. 5 | of 41 dangerous chemical substances includes the 33 priority
156 III, 10. 4. 5 | includes the 33 priority substances and 8 other pollutants.
157 III, 10. 4. 5 | contaminated with hazardous substances can have serious effects
158 III, 10. 4. 5 | the reduction of hazardous substances in material streams and
159 III, 10. 4. 5 | the types and amount of substances emanating from these sources.
160 III, 10. 4. 5 | large number of different substances, with only few of them produced
161 III, 10. 4. 5 | explosiveness. In addition to the substances above, they suggested that
162 III, 10. 5. 3 | hazardous physical and chemical substances and straining psychosocial
163 IV, 11. 5. 4 | exchange of therapeutic substances of human origin in 1958
164 IV, 11. 5. 6 | transplantation of human substances~ ~· Recommendation No. R (
165 IV, 12. 1 | and safety of organs and substances of human origin, blood and
166 IV, 12. 1 | the case of therapeutic substances of human origin. While at
167 IV, 12. 2 | thousands of other harmful substances found in cigarettes and
168 IV, 12. 5 | and quality of organs and substances of human origin, blood,
169 IV, 12. 10 | Human therapeutic substances: quality, safety and ethics~
170 IV, 12. 10 | disposal of the residual substances, both in the production
171 IV, 12. 10 | implementation will take. Chemical substances that pose a risk to human
172 IV, 12. 10 | handling of radioactive substances in nuclear technology and
173 IV, 12. 10 | narcotic drugs and psychotropic substances listed in the schedules
174 IV, 12. 10 | the schedules to the Act. Substances are scheduled under the
175 IV, 12. 10 | there is evidence that the substances are causing significant
176 IV, 12. 10 | Regulations 2004~- Control of Substances that deplete the Ozone Layer
177 IV, 12. 10 | 220 of 2003 - dangerous substances & preparations marketing
178 IV, 12. 10 | prohibition of certain active substances in plant protection products~ ~
179 IV, 12. 10 | 2037/2000 concerning the substances which destroy the layer
180 IV, 12. 10 | use of certain hazardous substances in electrical and electronic
181 IV, 12. 10 | Narcotic and Psychotropic Substances and Medical Products~ State
182 IV, 13. 2. 3 | than that caused by various substances found in the environment.
183 IV, 13. 2. 3 | 0175 (5)~PAHs (5) other substances~ ~Various substances~ ~ ~
184 IV, 13. 2. 3 | other substances~ ~Various substances~ ~ ~1. Here, ‘unhealthy
